WIPI Antikörper

WIPI-1 (WD repeat domain, phosphoinositide interacting-1) is thought to play a role in autophagy and may regulate protein trafficking in certain recycling pathways. In addition, WIPI-1 interacts with androgen and estrogen receptors. WIPI-2 specifically has a 7-bladed propeller and a motif for interaction with phospholipids. Expression of WIPI-2 is downregulated in pancreatic and kidney tumors. Upregulated in uterine and ovarian cancer, WIPI-3 contains two WD domains, seven WD40 domains, and is encoded by a gene that maps to human chromosome 17. WIPI-4 is a 360 amino acid protein containing three WD repeats. Existing as three alternatively spliced isoforms, WIPI-4 is ubiquitously expressed but found at highest levels in heart and skeletal muscle.