WDFY Antikörper

WDFY1 (WD repeat and FYVE domain containing 1)is a 410 amino acid protein that localizes to the early endosome and contains one FYVE-type zinc finger and seven WD repeats through which it may play a role in protein trafficking and signal transduction. The FYVE domain is a cysteine-rich domain of about 70 amino acids. Its primary role is to target signal-transducing proteins to cell membranes through binding to the membrane lipid phosphatidylinositol-3-phosphate with high specificity. WD-repeats are generally found in clusters of seven. They have no intrinsic catalytic activity, but they serve as a platform for protein-protein interactions. WDFY2 consists of one FYVE-type zinc finger and seven WD repeats. WDFY2 is suspected to play a critical role in the endocytic pathway. WDFY3 is a 3,526 amino acid protein that localizes to the cytoplasmic side of peripheral membranes. Ubiquitously expressed, WDFY3 colocalizes with autophagic structures in starved cells and is expressed in liver, brain and kidney. WDFY3 exists as two alternatively spliced isoforms and contains one BEACH domain, one FYVE-type zinc finger, a pair of LRR (leucine-rich) repeats and five WD repeats.