Rsf Antikörper

Remodeling and spacing factor 1 (Rsf-1) is a member of the chromatin-remodeling complex family of proteins that regulate gene expression and cell growth. Rsf-1 is a nuclear protein that acts as a histone chaperone and binds to another member of the chromatin-remodeling complex, hSNF2H. Together, this protein duplex regulates RNA transcription and DNA replication by both correctly spacing nucleosome arrays and by mobilizing nucleosomes when chromatin remodeling occurs. In reponse to hepatitis B infection, Rsf-1 can bind to the viral transcription activator pX, which then coactivates the transcription factor NF-kappaB, thus supporting the life cycle of the viral genome. Additionally, Rsf-1 is thought to be a potent oncogene, with elevated expression observed in ovarian carcinomas.