QTRT Antikörper

QTRTD1 (queuine tRNA-ribosyltransferase domain containing 1) is a 415 amino acid protein involved in tRNA modification and tRNA-queuosine biosynthesis. Localizing to cytoplasm, QTRTD1 also localizes to the mitochondrial outer membrane and associates with QTRT1 (queuine tRNA-ribosyltransferase domain containing 1) to form an active queuine tRNA-ribosyltransferase. At the wobble position of tRNAs with GUN anticodons, QTRTD1 exchanges queuine for guanine to form queuosine, a modified nucleoside. QTRTD1 is a member of the queuine tRNA-ribosyltransferase family, QTRTD1 subfamily and is encoded by a gene located on human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.