PMCA Antikörper

The plasma membrane Ca2+-pumping ATPase (PMCA) mRNAs are encoded on four genes designated PMCA1, PMCA2, PMCA3 and PMCA4. PMCA4b is the major PMCA expressed in developing mammary tissue. During lactation, PMCA1b expression increases while PMCA4b expression decreases, indicating that PMCAs play a critical role in maintaining cellular Ca2+ homeostasis. In addition, human PMCA4b may have an important role in regulating intracellular Ca2+ in the apoptotic cell. PMCA4b is cleaved at Asp 1080 by caspase-3 to produce a single fragment that is fully active, responding much faster to an increase in Ca2+ than the autoinhibited form. Both PMCA1 and PMCA4 are expressed at similar levels in astrocytes and in neurons.