NCOAT Antikörper

NCOAT (nuclear cytoplasmic O-GlcNAcase and acetyltransferase), also known as MGEA5 (meningioma-expressed antigen 5), HEXC or MEA5, is a bifunctional enzyme that functions as both a ∫-hexosaminidase and a histone acetyltransferase. Expressed ubiquitously with highest expression in placenta, brain and pancreas, NCOAT functions as a glycosidase that catalyzes the cleavage of O-GlcNAc residues from GlcNAc-modified proteins. In addition, NCOAT acetylates specific residues on Histone H3 and Histone H4, suggesting an important role in the histone code. The enzymatic activity of NCOAT is optimal at a slightly acidic pH of 5.7-7 and NCOAT function is competitively inhibited by free N-acetylglucosamine. Due to alternative splicing events, NCOAT is expressed as three isoforms. Isoform 1 localizes to the cytoplasm, while isoform 3 localizes to the nucleus.