LZP Antikörper

The epidermal growth factor (EGF) repeat-containing proteins constitute an expanding family of proteins that are involved in several cellular activities, such as blood coagulation, fibrinolysis, cell adhesion and neural and vertebrate development. LZP (liver-specific zona pellucida domain-containing protein), also known as OIT3 (Oncoprotein-induced transcript 3 protein), is a 545 amino acid protein that localizes to the nuclear envelope and contains one ZP domain and one EGF-like domain. Expressed specifically in liver tissue, LZP is thought to be involved in hepatocellular function and development and is down-regulated in hepatocellular carcinoma, suggesting an additional role in tumor suppression. Multiple isoforms of LZP exist due to alternative splicing events.