Ladinin Antikörper

LAD1 (linear IgA disease antigen), also known as Ladinin-1 or LADA, is a 517 amino acid secreted protein. Localized to the basement membrane zone of the extracellular space, LAD1 is an anchoring filament protein that is thought to contribute to the stability of the interaction of the epithelial layers with the mesenchyme. LAD1 is an autoantigen associated with linear IgA disease, in which circulating IgA autoantibodies recognize basement membrane zone proteins. LAD1 is expressed at highest levels in lung and kidney, with lower levels in spleen, liver and brain.