KCNG Antikörper

Neuronal and cardiac cells are excited by voltage-gated ion channels. Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. Mutations interfering with potassium ion channels are known to cause a variety of disorders. KCNG1 (potassium voltage-gated channel subfamily G member 1) is expressed as two isoforms and can be obtained from tissues including brain, placenta, kidneys and pancreas. KCNG1 is an å-subunit that does not form a functional potassium channel unless it is incorporated into a heteromultimer with KV2.1. The KCNG1-KV2.1 heterotetramer is able to form a unique, functional potassium channel. KCNG2 is abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and detected at lower concentrations in brain, lung and placenta. KCNG3 is detected in testis, pancreas, lung, kidney, ovary, small intestine, colon, thymus, adrenal gland, spinal cord and in many parts of the brain, with the exception of the cerebellum.