ICMT Antikörper

ICMT (isoprenylcysteine carboxylmethyltransferase), also known as PCCMT, HSTE14 or PPMT, is a 284 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and belongs to the isoprenylcysteine O-methyltransferase family. Expressed ubiquitously with highest expression in brain tissue, ICMT uses divalent cations (such as zinc) to catalyze the post-translational methylation of isoprenylated C-terminal cysteine residues. Specifically, ICMT functions as the third of three enzymes that modify isoprenylated C-terminal cysteine residues on target proteins, thereby targeting those proteins to the cell membrane. Inhibition of ICMT effects Ras function and causes endothelial apoptosis, an event that may lead to a decrease in oncogenic transformation. Multiple isoforms of ICMT exist due to alternative splicing.