Drebrin Antikörper

Drebrins (Developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes, and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A) that are generated by alternative RNA splicing from a single Debrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas, and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain are associated with Alzheimer’s disease and Down syndrome. The gene encoding for the human Drebrin protein is located on chromosome 5.