DBX Antikörper

DBX1 (developing brain homeobox 1) and DBX2 are members of the H2.0 homeobox protein family. Localized to the nucleus, DBX1 and DBX2 contain one homeobox DNA-binding domain. DBX1 is thought to play a role in patterning the central nervous system during embryogenesis. DBX1 is also involved in the regulation of the distinct phenotypic features that distinguish two major classes of ventral interneurons, designated V0 and V1 neurons. DBX1 regulates the neurotransmitter phenotype, transcription factor profile, intraspinal migratory path and axonal trajectory of V0 neurons, which distinguishes them from V1 neurons. DBX2, which is expressed in the forebrain, midbrain, hindbrain and spinal cord, has been implicated in CNS development. Specifically, DBX2 has been shown to play a role in spinal cord dorsal/ventral patterning, as well as the regionalization of the CNS. DBX2 is also thought to play a role in the production of multiple spinal cord cell types.