Carbonyl reductase Antikörper

Carbonyl reductase 1 and Carbonyl reductase 3 belong to the family of short-chain dehydrogenase/reductase proteins that play a role in metabolism throughout the body. Both proteins are monomeric carbonyl reductases that function to catalyze the NADPH-dependent reduction of various carbonyls (generally products of lipid peroxidation) to their corresponding alcohols. Carbonyl reductase 1 and Carbonyl reductase 3 share high sequence similarity at the amino acid level and are responsible for the metabolism of not only endogenous compounds, but of various pharmacological products, as well. Genetic polymorphisms in both proteins result in individual variability at the level of drug metabolism. Defects in the genes encoding Carbonyl reductase proteins have implications in cancer, diabetes and errors in metabolism.