Calbindin Antikörper

The family of EF-hand type Ca²⁺-binding proteins include Calbindin D28K and Calbindin D9K as well as several other members. Calbindin D28K acts as a calcium-buffering agent and alters the activity of the plasma membrane ATPase. In neuronal cells, Calbindin D28K modulates calcium channel activity, calcium transients and intrinsic neuronal firing activity. Also, Calbindin D28K has been implicated to play a role in apoptosis and microtubule function. Rat Calbindin D9K binds the estrogen receptor because the gene encoding it contains an estrogen response element downstream from its promoter. In contrast, the homologous human sequence differs by two essential nucleotides and does not bind the estrogen receptor, suggesting that this change suppresses gene expression in human tissues, such as uterus and possibly placenta.