Barhl Antikörper

Drosophila gene BarH1 contains a homeobox required for external sensory organ fate determination. Barhl1 (BarH-like-1) is hypothesized to play a similar role in mouse and human development. In the developing CNS, the expression of Barhl1 in migrating cells gives rise to the cerebellar external granular layer. Barhl2 localizes to the nucleus and is expressed in the central nervous system as well as in mature and differentiating amacrine, horizontal and ganglion cells of the retina. Barhl2 plays a role in regulating the specification of glycinergic amacrine cells and controls horizontal cell differentiation. Barhl2 may also be involved in the regulation of neural basic helix-loop-helix genes.