| PRODUKT |
CATALOG # |
DESCRIPTION |
AMOUNT |
|
sc-201327 |
A structural analog of endothall, which shows no inhibition of PP2A activity. Useful negative control for endothall and cantharidin. |
10 mg/50 mg |
|
sc-220885 |
A protein tyrosine phosphatase inhibitor that enhances growth factor-induced differentiation in PC12 cells possibly by sustaining MAP kinase activity. Can also be used as a protein S-nitrosylating agent and exhibits greater stability than Dephostatin. |
1 mg |
|
sc-220886 |
A more stable ethyl analog of 3,4-Dephostatin. Potently inhibits protein tyrosine phosphatase 1B. |
1 mg |
|
sc-220931 |
A substrate for the electrochemical measurement of alkaline phosphatase. |
10 mg |
|
sc-221017 |
A histochemical substance used to visualize alkaline phosphatase activity. Hydrolysis of the phosphate group by alkaline phosphatase generates an insoluble indigo compound. |
100 mg/250 mg |
|
sc-202038 |
A membrane permeable compound that acts as an antagonist in the activation of cAMP-dependent protein kinase (PKA). Also shown to inhibit dcAMP- and Sp-cAMPS-induced stimulation of bone resorption in mice. |
5 µmol |
|
sc-202898 |
Reported to be an alkaline, acid, and protein phosphatase inhibitor. Also been shown to dephosphorylate the actin-depolymerizing protein, Cofilin 1, in platelets. |
5 g |
|
sc-201329 |
A derivative of artemisinin with anti-microbial properties |
10 mg/50 mg |
|
sc-200588 |
A protein tyrosine phosphatase (PTP) inhibitor that also inhibits COX-1 and COX-2. |
100 mg/500 mg |
|
sc-221349 |
A bis-acetoxymethyl ester (AM) derivative of benzylphosphonic acid which is cell permeable and is converted to the active phosphonic acid via intracellular esterase-catalyzed cleavage of the AM esters. |
10 mg/50 MG |
|
sc-263025 |
|
5 g |
|
sc-203323 |
A simple phosphate donor, acts as an inhibitor to phosphatase and as a source of phosphate for biological studies. |
50 g/100 g |
|
sc-221376 |
This is a protein phosphotyrosine phosphatase inhibitor. |
5 mg/25 mg |
|
sc-221377 |
This is a protein phosphotyrosine phosphatase inhibitor. |
5 mg |
|
sc-221378 |
A peroxovanadium insulin mimetic compound. Inhibits the dephosphorylation of insulin receptors by blocking protein phosphotyrosine phosphatase activity. |
5 mg/25 mg |
|
sc-221379 |
A vanadate molecule coordinated to picolinic acid (2-carboxypyridine) and potassium, that is thought to act as an insulin mimetic. |
5 mg/25 mg |
|
sc-203536 |
Non-competitive protein tyrosine phosphatase inhibitor; enhances insulin signalling and insulin tolerance in ob/ob mice. Displays irreversible inhibition via catalysis of hydrogen peroxide-dependent oxidation of PTP. |
10 mg/50 mg |
|
sc-221392 |
A photo-activated derivative of Ins(1,4,5)P3. It is not biologically active or metabolized by endogenous phosphatase. |
10 µg |
|
sc-24000 |
Shown to increase the degree of phosphorylation of Histone H3, PRK2 and beta-catenin; while also acting as a potent, cell permeable, inhibitor of protein phosphatase 1(EC50), 2A and the endogenous phosphatase of smooth muscle myosin B; EC50 = 8nM, 0.3 nM and 0.7 nM respectively. |
10 µg/100 µg |
|
sc-201323 |
An analog of cantharidin (CA) that is a potent and selective inhibitor of protein phosphatase (PP2A) and protein phosphatase 1 (PP1). Does not inhibit PP2B or PP2C. |
10 mg/50 mg |
|
sc-201321 |
A small molecule herbicide and potent inhibitor of PP2A (IC50=40 nM). |
25 mg/100 mg |
|
sc-202987 |
A cell-permeable, potent, irreversible and mixed competitive inhibitor of the CDC25 phosphatase family. Exhibits anti proliferative properties and induces reactive oxygen species in mammalian cells. |
5 mg |
|
sc-3527 |
Ceramide C6 has shown to activate MAP kinase and PP2A along with apoptosis of Molt-4 and HL-60, enhance COX-2 in rats and aortic smooth muscle in bovines, suppress Tyr Phospohorylation and inhibit glycoprotein traffic. |
5 mg/25 mg |
|
sc-205633 |
CinnGEL 2Me is a cell permeable protein tyrosine phosphatase-1B (PTP1B) inhibitor. |
1 mg |
|
sc-24012 |
A potent inhibitor of calcineurin (protein phosphatase 2B). |
10 mg/50 mg |
|
sc-24013 |
A Type II pyrethroid insecticide that potently inhibits calcineurin with an IC50 of 10-9 to 10-11 M. |
10 mg/50 mg |
|
sc-202131 |
PTP inhibitor. Competitively inhibits PTP activity in membrane preparations from human neoplastic T cell line. Reported to mobilize intracellular calcium. Stable NO donor for S-nitrosylation of proteins |
1 mg |
|
sc-221582 |
A potent cell-permeable analog of the eIF2α phosphatase inhibitor Salubrinal (sc-202332), with enhanced aqueous solubility, that has been shown to prevent the dephosphorylation of eIF-2α. |
5 mg |
|
sc-201325 |
A small molecule herbicide and inhibitor of PP2A (IC50=970 nM). |
20 mg/100 mg |
|
sc-24014 |
A type II pyrethoid. Potent inhibitor of calcineurin, suggested activity at GABA receptors as benzodiazepine agonists, and other potential synaptic and neuronal activity. |
25 mg/100 mg |
|
sc-201431 |
An inhibitor of non-specific alkaline phosphatase. Also shows inhibition of tyrosine phosphatases. |
5 mg/50 mg |
|
sc-200312 |
Releases phosphate groups from phosphorylated serine, threonine and tyrosine residues in proteins; also active on phosphorylated histidine residues |
0.25ml/ 0.05ml |
|
sc-221874 |
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM). |
5 mg/25 mg |
|
sc-221958 |
A protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. |
10 mg |
|
sc-203654 |
A selective and effective dual-specificity, quinone-based phosphatase inhibitor. The compound has been reported to inhibit Cdc25A, B and C. |
10 mg/50 mg |
|
sc-3513 |
Potent and selective inhibitor of PP1 and PP2A phosphatases; reduces outgrowth of PC12 cells. |
25 µg/100 µg |
|
sc-202259 |
A dinoflagellate toxin and potent inhibitor of PP1A and PP2A/B. A known tumor promoter. |
25 µg/100 µg |
|
sc-202260 |
Shown to be a protein phosphatase regulator via non-competitive or mixed inhibition of the okadaic acid-sensitive enzymes. Also reported to induce ornithine decarboxylase in mouse skin |
25 µg |
|
sc-358718 |
50X liquid alkaline phosphatase substrate used in ELISA applications; absorbs light at 405nm. |
10 ml |
|
sc-201319 |
A common pesticide. Causes prolonged activation of Na+ channels disturbing neuronal function. |
10 mg/50 mg |
|
sc-222189 |
A cell-permeable benzylidene rhodanine compound that potently inhibits hPRL-3, a member of the regenerating liver family tyrosine phosphatases. Shown to reduce the invasiveness of murine melanoma B16F10 cells. |
10 mg |
|
sc-222223 |
A cell-permeable, potent, selective, competitive, and reversible inhibitor of CD45. Does not effectively inhibit PTPIB and the phenanthrenedione group does not function as a thiol oxidizing agent. |
1 mg |
|
sc-204220 |
A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB. |
10 mg |
|
sc-202784 |
A cell-permeable, covalent and potent protein tyrosine phosphatase (PTP) inhibitor. |
25 mg |
|
sc-222224 |
A cell-permeable compound that inhibits a broad-range of protein tyrosine phosphatases (PTPs). |
10 mg |
|
sc-222225 |
An uncharged, 1,4-di-substituted, phenyl-linked bis-trifluoromethylsulfonamido (TFMS) phosphate mimetic which acts as a potent, reversible, competitive, and active-site directed inhibitor of protein tyrosine phosphatases. |
10 mg |
|
sc-222227 |
An inhibitor that blocks the activity of enzyme PTP1B, a key factor in the negative regulation of insulin and leptin signaling pathway. |
5 mg |
|
sc-202312 |
Has been reported to be a potent inhibitor of the neural calcium-calmodulin-dependent protein phosphatase, calcineurin. Also shown to eliminate constitutive nitric oxide release from lobster heart. |
10 mg/25 mg |
|
sc-202319 |
An inhibitor of protein tyrosine phosphatase, blocking dephosphorylation of CD45 and VHR. Inhibitor of heparanase activity. |
200 µg/1 mg |
|
sc-202791 |
An effective tyrosine phosphatase inhibitor that does not permeate the cell membrane. |
200 µg |
|
sc-222266 |
RWJ-60475 is an inhibitor of the CD45 tyrosine phosphatase (IC50=2 µM). It is not cell permeable. It is a hydrolytically stable bioisostere of phosphotyrosine which binds to the CD45 catalytic site. |
5 mg/25 mg |
|
sc-222267 |
A cell-permeable acetoxymethyl (AM) ester of RWJ-60475. The AM esters promote cell membrane permeability and are hydrolyzed by intracellular esterases which traps the active inhibitor within the cell. |
1 mg |
|
sc-202332 |
Cell permeable and selective inhibitor of eIF-2α, shown to protect cells from ER stress-induced apoptosis induced by tunicamycin (sc-201539), and brefeldin A (sc-200861). |
1 mg/5 mg |
|
sc-24988 |
Sodium Fluoride (NaF) is an inhibitor of serine/threonine phosphatases. Also an activator of G proteins. NaF is widely studied in bone and dental research. |
125 g/5 g/500 g |
|
sc-3540 |
Inhibitor of ATPase, alkaline phosphatase (ALP) and protein tyrosine phosphatases (PTPs). Routinely used to preserve the PTP state in cells, cell lysates, and PTK assays. |
5 g |
|
sc-202815 |
A robust inhibitor of PTPases, including PTPase1 (SHP-1), SHP-2, and PTP1B. Also augments cytokine response and forms a complex with PTPase. |
1 g |
|
sc-200587 |
Potent and selective protein phosphatase inhibitor that functions as an antifungal antibiotic. Shows greater inhibition for PP1 versus PP2, and can activate the Raf-1 pathway. |
25 µg |
|
sc-222407 |
This reduces hydrophobic bile acids as well as decreases lymphocyte reactivity and serum alkaline phosphatase levels when used in the treatment for primary biliary cirrhosis. I interferes with ileal absorption of toxic endogenous bile acids. |
1 g |
