| ABT 751 | |
| Catalog # | CAS | Formula | Unit |
| sc-361097 | 141430-65-1 | C18H17N3O4S | 10 mg/50 mg |
(+)-Blebbistatin
The inactive enantiomer of (±)-Blebbistatin. | |
| Catalog # | CAS | Formula | Unit |
| sc-311293 | 1177356-70-5 | C18H16N2O2 | 1 mg |
| BMS 195614 | |
| Catalog # | CAS | Formula | Unit |
| sc-362715 | 253310-42-8 | C29H24N2O3 | 10 mg/50 mg |
Cdk2/9 Inhibitor
A cell-permeable aminopyrimidinyl compound that acts as a potent and ATP-competitive inhibitor of Cdk2/E and Cdk9/T1. Also inhibits GSK-3β, Cdk4/D, Cdk7/H, Cdk1/B, and Abl at higher concentrations, but exhibits little activity towards 9 other kinases. Shown to inhibit phosphorylation of cellular Cdk substrates, pRb and RNA polymerase II, and Cdk2-mediated S-phase transition. | |
| Catalog # | CAS | Formula | Unit |
| sc-221411 | 507487-89-0 | C14H12N6O2S | 5 mg |
Cycloheximide
Has been reported to inhibit synthesis of proteins, additional macromolecules and to affect apoptosis in eukaryotes. | |
| Catalog # | CAS | Formula | Unit |
| sc-3508 | 66-81-9 | C15H23NO4 | 1 g/5 g/100 mg |
Cytochalasin A
Fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. Inhibits transport of monosaccharides across the cell membrane. | |
| Catalog # | CAS | Formula | Unit |
| sc-204705 | 14110-64-6 | C29H35NO5 | 1 mg/5 mg |
cytochalasin B
Cytochalasin B is a metabolite of the fungus Drechslera dematoidea which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-3519 | 14930-96-2 | C29H37NO5 | 5 mg |
Cytochalasin C
Fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-202118 | 22144-76-9 | C30H37NO6 | 1 mg/5 mg |
Cytochalasin D
Cell-permeable fungal toxin that binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-201442 | 22144-77-0 | C30H37NO6 | 1 mg/5 mg |
Cytochalasin E, Aspergillus clavatus
Fungal metabolite which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-202561 | 36011-19-5 | C28H33NO7 | 1 mg |
Cytochalasin H
Potent mycotoxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-202119 | 53760-19-3 | C30H39NO5 | 1 mg |
Cytochalasin J
Potent mycotoxin which binds to the barbed end of actin filaments inhibiting both the association and dissociation of subunits. Used as a tool for cytological research. | |
| Catalog # | CAS | Formula | Unit |
| sc-202120 | 56144-22-0 | C28H37NO4 | 1 mg |
Dihydrocytochalasin B
Induces changes in cell morphology and motility with no effect on sugar transport. Used as specific marker in studies of high affinity cytochalasin binding sites unrelated to sugar transport. | |
| Catalog # | CAS | Formula | Unit |
| sc-202579 | 39156-67-7 | C29H39NO5 | 1 mg |
Eg5 Inhibitor V, trans-24
Cell-permeable HR22C16 derivative that exhibits enhanced potency against mitotic kinesin Eg5-ATPase activity and little activity against 9 other kinesins. Induces monoastral phenotype in HeLa cells. | |
| Catalog # | CAS | Formula | Unit |
| sc-202596 | 869304-55-2 | C26H21N3O3 | 5 mg |
Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1
A cell-permeable thiazolyl benzamide compound that preferentially targets Hec1, disrupts Hec1/Nek2 complex, and destabilizes Nek2 leading to defective localization of Hec1 at kinetochores. Shown to induce transient mitotic arrest, and inhibit the proliferation of several breast cancer cells with a GI50 of 10 - 21 µM; further, reduce tumor outgrowth in a xenograft mouse model (50 mg/kg, i.p.). | |
| Catalog # | CAS | Formula | Unit |
| sc-221711 | n.n. | C18H16N2OS | 10 mg |
Indole-3-carbinol
A cell growth inhibitor that reversibly suppresses incorporation of [3H]thymidine. Reported to induce G1 cell cycle arrest and block expression of cyclin-dependent kinase 6 in cells. | |
| Catalog # | CAS | Formula | Unit |
| sc-202662 | 700-06-1 | C9H9NO | 100 mg |
Methotrexate
A cell cycle arrest agent that inhibits DHFR and modulates inflammation through adenosine promotion and transmethylation reaction inhibition. Also attenuate IL-1 expression. | |
| Catalog # | CAS | Formula | Unit |
| sc-3507 | 59-05-2 | C20H22N8O5 | 100 mg/500 mg |
Olomoucine
A purine that acts as a competitive inhibitor of a variety of cell cycle regulating proteins with high specificity, which leads to the blockage of some cell cycle steps. | |
| Catalog # | CAS | Formula | Unit |
| sc-3509 | 101622-51-9 | C15H18N6O | 5 mg/25 mg |
PNC-28
A decapeptide derived from the N-terminal MDM-2 binding domain of p53, residues 17 - 26, and linked to the Antennapedia leader sequence at the C-terminal. Exerts anti-proliferative activities. Directly binds to MDM-2 and induces non-apoptotic cell-death (IC0) = 40 µg/ml in TUC-3 cells) that is independent of p53 activation. Reported to have no effect on the growth of normal cells. | |
| Catalog # | CAS | Formula | Unit |
| sc-222123 | n.n. | C164H255N47O37S | 500 µg |
PPIase-Parvulin Inhibitor
A cell-permeable napthalenetetracarboxylic-bisimide compound that displays anti-proliferative properties. Causes cell cycle arrest and acts as a potent, competitive, selective, reversible, active site binding inhibitor of Pin1/Par14 PPIase (peptidyl prolyl cis-trans isomerase) activity. | |
| Catalog # | CAS | Formula | Unit |
| sc-222187 | n.n. | C22H18N2O8 | 10 mg |
T113242
A cell-permeable pentafluorosulfonamide compound that induces microtubule depolymerization and cell-cycle arrest by irreversibly modifying β-tubulin. T113242-induced activation of gene transcriptions has been shown to be mediated by Erk signalling pathway and the transcription factor MIZ-1 (myc-interacting zinc finger protein). | |
| Catalog # | CAS | Formula | Unit |
| sc-222335 | n.n. | C14H11F5N2O2S | 10 mg |
Tubulin Polymerization Inhibitor II
A cell-permeable, SU5416 (sc-202851) derived combretastatin A-4 analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin). Has also been shown to exhibit extremely potent anti-proliferative activity towards various cancer cell lines (GI50 <10 nM for 46 lines among a 53 NCI panel tested). | |
| Catalog # | CAS | Formula | Unit |
| sc-296673 | n.n. | C19H19NO5 | 5 mg |
Tunicamycin
A mixture of tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. | |
| Catalog # | CAS | Formula | Unit |
| sc-3506 | 11089-65-9 | C38H62N4O16 ·(Tun ·B) | 10 mg |
| Vinorelbine ditartrate | |
| Catalog # | CAS | Formula | Unit |
| sc-361397 | 125317-39-7 | C45H54N4O8.2C4H6O6 | 10 mg/50 mg |
