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1-Octanesulfonic acid sodium salt sc-251529 Ion-pairing reagent for HPLC analysis of peptides and proteins.
2-Cyclohexylethyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside sc-280271
4-n-Octylbenzoylamido-propyl-dimethylammoniosulfobetaine sc-216955 A Zwitterionic detergent that stabilizes and solubilizes integral membrane proteins by breaking aggregates. Useful for protein analysis and characterization using 2D-gel electrophoresis and mass spectrometry. Superior to CHAPS in solubilization.
4-Oxo-3-(tetrahydro-furan-2-ylmethyl)-10-oxa-3-aza-tricyclo[5.2.1.0*1,5*]dec-8-ene-6-carboxylic acid sc-316954
APO-10 sc-280600 Novel non-ionic detergent useful for plasmid DNA isolation. Plasmid DNA isolated using APO-10 does not require the use of phenol/chloroform or proprietary resins. Provides excellent yields of high quality DNA. Allows plasmid DNA to be sequenced through difficult regions without the need to subclone into single-stranded vectors.
APO-12 sc-280601 Non-ionic detergent useful in two-phase separation and purification of proteins.
ASB-14 sc-252390 Zwitterionic detergent. Useful for solubilization of proteins, including membrane proteins, for 2D electrophoresis.
ASB-16 sc-280603 A zwitterionic amidosulfobetaine detergent useful for solubilizing proteins visualized by 2D-electrophoresis. The increased solubilization produced by this detergent enables the identification of previously undetected membrane proteins.
ASB-C7BzO sc-280604 A zwitterionic detergent whivch contains hydroxypropyl group between alkylphenyl hydrophobic tail and ammonio-propane sulfone hydrophilic head. Useful for solubilizing and stabilizing integral membrane proteins by disrupting aggregates. Reported to be compatible with urea (~7 M) and has been used successfully to extract A. thaliana leaf plasma membrane proteins and band III, a 100 kDa erythrocyte polytransmembrane protein, by two-dimensional electrophoresis (2-DGE).
Benzethonium hydroxide solution sc-280610 ~1.0 M in methanol Used in scintillation experiments.
Big CHAP sc-280621 Non-ionic detergent analog of CHAPS and CHAPSO with significantly reduced electrostatic interactions that do not interfere in anion exchange chromatography on DEAE-cellulose.
Brij 35 sc-280628 A polyglycol ether which functions as a detergent for the isolation of functional cell membrane complexes.
Bt3(1,3,5)IP3/AM sc-280630 Novel analogs capable of exhibiting Ins(1,4,5)P3-like agonist or antagonist effects on calcium release are more resistant to hydrolysis and metabolic degradation than IP3 or IP4. Consequently, they can produce a prolonged activation of cellular processes dependent on the Ins(1,4,5)P3 receptor interaction. These tools are important in the elucidation of the molecular interactions of Ins(1,4,5)P3 with its intracellular receptor and with Ins(1,4,5)P3-kinase and 5-phosphatase. Acetoxymethyl esters of inositol phosphate are highly lipophilic. Hence, they easily diffuse through the cell membrane. Note: Each set contains 1 µmol of Bt3(1,3,5)IP3/AM and 10 mg of PLURONIC F-127 detergent to aid in the solubilization of this product.
C12E8 sc-280634 Non-ionic detergent useful for solubilization of membrane-bound proteins in their native state.
Cetyltrimethylammonium Bromide sc-278833 A cationic detergent suitable for the isolation of high molecular weight DNA in plants and other organisms.
CHAPSO sc-280635 A unique detergent with high CMC that solubilizes membrane-bound proteins in their native state. Capable of solubilizing opiate receptor to a state exhibiting reversible binding of opiates. Has higher solubility than CHAPS because of its more polar head group.
Chenodeoxycholic acid diacetate methyl ester sc-280636
Chenodeoxycholic Acid, Sodium Salt sc-280637 Bile acid that has been shown to increase intracellular Ca2+ in isolated rat hepatocyte couplets. Induces a permeability transition in freshly isolated rat liver mitochondria.
Cholic acid sc-255020 Non-denaturing ionic detergent used for extraction of membrane proteins. Bile Acid
Cholic Acid, Sodium Salt sc-280641 Primary bile acid.
Choline p-toluenesulfonate salt sc-281523 A useful intermediate as well as a choline acetyltransferase (CHAT) substrate. May be used with organic solvents.
Cyclohexyl-n-hexyl-β-D-maltoside sc-280651 A detergent designed specifically for the purification and crystallization of membrane-bound proteins in their native state. Has a higher CMC value than the corresponding linear chain containing the same number of carbons, providing higher hydrophobicity in a shorter effective chain length.
Cyclohexylmethyl-4-O-(a-D-glucopyranosyl)-b-D-glucopyranoside sc-280652
DDMAB sc-280663 Water-soluble zwitterionic detergent with properties similar to DDMAU but differing in the length of the polymethylene arm. More efficient for the extraction of mycoplasma membrane antigens under mild conditions than DDMAU.
Decyl b-D-maltopyranoside sc-280666
Decyl b-D-thioglucopyranoside sc-280667
Decyl-β-D-1-thiomaltopyranoside sc-280668 Detergent for the purification, extraction and solubilization of membrane-bound proteins in the native structure. It increases solubilization by dissociating aggregates and is easily removed by dialysis.
Deoxycholic Acid, Sodium Salt sc-280670 An ionic detergent for the solubilization of membrane-bound proteins. Reported to induce tyrosine phosphorylation of b-catenin and its subsequent translocation to the nucleus, promoting activation of b-catenin signaling (effective concentration 5-50 µM).
Diethylene glycol monohexyl ether sc-280674
Diethylene glycol monopentyl ether sc-326822
Digitonin sc-280675 A non-ionic detergent commonly used to solubilize membrane-bound proteins.
Digitoxigenin sc-255098
Dimethylethylammoniumpropane sulfonate sc-300486 This product is a compound used for non-denaturing protien purification.
Eicosyltriethylammonium Bromide sc-280683
ELUGENT Detergent, 50% Solution sc-280685 A non-ionic detergent composed of a mixture of alkyl glucosides. Like n-octyl-β-D-glucopyranoside and TRITON X-100 Detergent, it is useful for solubilization and purification of membrane-bound proteins. Relatively low cost alternative to n-octyl-β-D-glucopyranoside and n-octyl-β-D-maltoside in large-scale solubilizations. HLB number: 13.1.
Ethylene glycol monodecyl ether sc-280713 Non-ionic surfactant which effectively releases histamine from rat peritoneal mast cells.
Ethylene glycol monododecyl ether sc-280714 Non-Ionic surfactant.
Ethylene glycol monohexadecyl ether sc-257517
Ethylene glycol monohexyl ether sc-280715
Ethylhexadecyldimethylammonium bromide sc-280717
GENAPOL X-080, 10% Solution, Sterile-Filtered sc-280726 These detergents have been purified for the isolation of membrane proteins (cloud point: 74–76°C in water; HLB number: 13-14). They can be used in protocols that require UV monitoring of the solubilized proteins because of their low UV absorbance. Since several investigators have reported problems associated with peroxide and aldehyde impurities in polyoxyethylene detergents, these GENAPOL Detergents have been additionally purified to reduce levels of contaminating peroxides, aldehydes, metals, and salts (aldehyde concentration: < 200 µM; peroxide concentration: < 200 µM; conductivity: < 50 µmhos). CMC 60 - 150 mM.
GENAPOL X-100, 10% Solution, Sterile-Filtered sc-280727 GENAPOL Detergents are polyglycol ethers with the general formula R-CH2-O-(CH2CH2O)nH, where n = the number of ethylene oxides. These detergents have been purified for the isolation of membrane proteins. They can be used in protocols that require UV monitoring of the solubilized proteins because of their low UV absorbance. Since several investigators have reported problems associated with peroxide and aldehyde impurities in polyoxyethylene detergents, these GENAPOL Detergents have been additionally purified to reduce levels of contaminating aldehydes, peroxides, metals, and salts (aldehyde concentration: < 200 µM; peroxide concentration: < 200 µM; conductivity: < 50 µmhos).
Glucopone 600 CS UP solution sc-252856
Glycocholic Acid, Sodium Salt sc-280754 Formed by the conjugation of cholic acid with glycine.
Glycodeoxycholic Acid, Sodium Salt sc-280755 Induces apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases.
Hexadecyltrimethylammonium p-toluenesulfonate sc-280770
Hexaethylene glycol monodecyl ether sc-280771
Hexaethylene glycol monododecyl ether sc-252881 A non-ionic surfactant which effectively releases histamine from rat peritoneal mast cells.
IGEPAL CA-630 sc-280818 A non-ionic detergent and emulsifier.
Lauroyl-DL-carnitine chloride sc-280906 A zwitterionic acylcarnitine detergent. Demonstrates enhancement of mucosal absorption of molecules.
Lauroylsarcosine, Sodium Salt sc-280907 Ionic detergent used to purify membrane proteins. Also decreases transcription efficiency.
LPD-12 sc-280941 A water soluble, amphiphilic α-helical lipopeptide detergent (LPD) that forms small micelles and effectively mimics lipid bilayers (solubility in PBS ~ 40 mM). Shown to not only solubilize but also stabilize bacteriorhodopsin, lactose permease and E. coli PagP protein ([LPD] ~ 250 µM and [protein] ~ 22 µM) by forming complexes and precluding aggregation. Useful for NMR and X-ray structural studies of membrane proteins.
MEGA-8 sc-280957 Water-soluble detergent with nondenaturing properties. Can be readily removed by dialysis. Useful reagent for membrane research.
MEGA-9 sc-280958 Water-soluble detergent with nondenaturing properties. Can be readily removed by dialysis. Useful reagent for membrane research.
Methoxypolyethylene glycol 350 sc-255268 Special Molecular Weight Info: average mol wt 350
Methylbenzethonium chloride sc-280989
N-Decanoyl-N-methylglucamine sc-281067 Water-soluble detergent with high solubilizing power and nondenaturing properties. Can be readily removed by dialysis. Useful reagent for membrane research.
n-Dodecyl α-D-maltoside sc-281069
n-Dodecyl-b-D-maltoside sc-281071 A non-ionic surfactant, forms useful micelles for stabilization and solubilization of proteins.
n-Dodecyl-β-D-glucopyranoside sc-281070 Highly purified non-ionic detergent for solubilization of membrane-bound proteins in their native state.
n-Heptyl-β-D-glucopyranoside sc-281075 Non-ionic detergent useful for the solubilization of membrane-bound proteins in their native state and for the preparation of lipid vesicles.
n-Hexadecyl β-D-maltoside sc-281076 Detergent for the purification, extraction and solubilization of membrane-bound proteins in the native structure. It increases solubilization by dissociating aggregates and is easily removed by dialysis: N.C. Robinson et al., Biochemistry, 24, 6298 (1985)
n-Hexyl-β-D-glucopyranoside sc-281077 Mild non-ionic detergent.
n-Nonyl-β-D-glucopyranoside sc-281084
N-Octanoyl-β-D-glucosylamine sc-281086
n-Octanoylsucrose sc-281088 Non-ionic detergent useful for solubilization of membrane-bound proteins in their native state. Easily removed by dialysis.
n-Octyl-b-D-glucopyranoside sc-281091 Non–ionic detergent intended for solubilizing membrane–bound proteins in their native state and for the preparation of lipid vesicles. Its well–defined chemical structure, small uniform micelles, and high water solubility make it superior to most other nonionic detergents for membrane solubilization. Because of its high critical micelle concentration (20-25 mM), it has the additional advantage of being removed easily by dialysis when compared to bile salts.
n-Octyl-oligo-oxyethylene sc-286437 Detergent for solubilization, purification and crystallization of membrane proteins.
n-Octyl-β-D-maltopyranoside sc-281089 Water-soluble non-ionic detergent suitable for solubilization and isolation of membrane proteins. Closely related to n-octyl-β-D-glucopyranoside (CMC 20-25 mM) and n-dodecyl-β-D-maltopyranoside (CMC 100 - 600 µM). Contaminants: n-octanol < 0.05% (HPLC). Aggregation number 6. CMC 19.5 mM.
n-Octyl-β-D-thioglucopyranoside sc-281090 Non-ionic detergent that has been used to isolate membrane proteins from E. coli without inactivation. Stable in aqueous solution and easily removed by dialysis. Highly purified and intended for use as a detergent to solubilize membrane-bound proteins in their native state.
n-Octylglucoside sc-29103 Mild, non-denaturing detergent for the solubilization and reconstitution of membrane proteins.
n-Undecyl β-D-glucopyranoside sc-281096
N,N-Dimethyloctadecylamine N-oxide solution sc-281100 Non-ionic surfactant
NDSB-195 sc-205912 A member of the class of nondetergent sulfobetaines. Unlike CHAPS and other zwittergents, NDSBs are nondenaturing even at 1 M concentrations.
NDSB-211 sc-205913 A non-detergent sulfobetaine useful for protein solubilization and stabilization of halophilic proteins.
NDSB-221 sc-222051 A non-detergent sulfobetaine (NDSB) useful for the renaturation of unfolded proteins.
NDSB-256 sc-204120 Nondetergent sulfobetaines class member; nondenaturing. Reported to prevent protein aggregation and facilitate the renaturation of chemically and thermally denatured proteins.
Sodium tetradecyl sulfate sc-253187 Alkyl sodium sulfate surfactant.
NDSB-256-4T sc-222052 A non-detergent sulfobetaine (NDSB) that prevents protein aggregation and facilitates protein-folding, presumably by interacting with the early folding intermediates. Shown to improve the in vitro renaturation efficiency of reduced hen lysozyme and chemically unfolded tryptophan synthase β2 subunit.
Nonaethylene glycol monododecyl ether sc-281106
Nonidet® P40 (substitute) sc-29102 Nonionic, non-denaturing detergent suitable for for solubilizing and isolation of membrane proteins. Chemically indistinguishable from Nonidet P-40, which is no longer commercially available.
Nonyl-β-D-1-thiomaltoside sc-281107 n-Nonyl-β-D-thiomaltoside is a newly developed detergent whose lipophilic moiety is maltose. This reagent is suitable for isolating proteins inside of cell membranes. The activity of protein isolated using n-Nonyl-β-D-thiomaltoside is higher than those isolated using n-Octyl-β-D-thioglucoside or n-Heptyl-β-D-thioglucoside. As the CMC value of this detergent is 2.4 mM, it is easy to remove from protein solutions by dialysis.
Nonylphenyl-polyethyleneglycol acetate sc-281568 Plasticizer for embedding bone-containing tissue for histochemistry.
NP-40 Alternative sc-281108 An alternative form of Nonidet P-40, which functions as a polyglycol ether (nonionic) surfactant that is useful in isolating and purifying membrane proteins in two dimensional gel electrophoresis.
Octaethylene glycol monodecyl ether sc-281111
Octaethylene glycol monooctadecyl ether sc-281112
Octylthiogalactoside sc-281113 Non ionic detergent used for solubilizing proteins.
Oxyphenonium bromide sc-281114 A quaternary ammonium antimuscarinic & anticholinergic agent with peripheral side effects similar to those of Atropine. Used as an adjunct in the treatment of gastric and duodenal ulcer, and to relieve visceral spasms. Has also been used in the form of eye drops for mydriatic effect.
Pentaethylene glycol monodecyl ether sc-281125
Pentaethylene glycol monooctyl ether sc-281126
PLURONIC F-127, 10% Solution, Sterile-Filtered sc-281131 A non-ionic detergent useful for isolation of membrane proteins. Has been used to solubilize large dye molecules in physiological media. Because of its low UV absorbance, can be used in protocols that require UV monitoring of the solubilized proteins.
Polyoxyethylene (10) tridecyl ether sc-281132
Polyoxyethylene (25) propylene glycol stearate sc-281133
Polyoxyethylenesorbitan monopalmitate sc-255442 Non-ionic detergent used for cell lysis, cell fractionation and nuclei isolation. Special Molecular Weight Info: estimated mol wt 1277
Polysorbat 60 sc-281134
Polysorbate 80 sc-255444 Non ionic detergent used for cell lysis, nuclei isolationand cell fractionationBulk pricing available
Saponin sc-280079 A secondary metabolite, which facilitates the penetration of proteins through the cell membrane.
Sodium 1-heptanesulfonate sc-253570 Ion-pairing reagent for HPLC, including analysis of proteins and peptides.
Sodium deoxycholate monohydrate sc-253579
Sodium taurodeoxycholate hydrate sc-253596 A bile salt-related, anionic detergent used for isolation of membrane proteins (including inner mitochondrial membrane proteins).
Sodium taurohyodeoxycholate hydrate sc-281149
Sorbitan monolaurate sc-281151 Monoester of lauric acid and hexitol anhydrides derived from sorbitol.
Sorbitan monostearate sc-281152
Sorbitan monooleate sc-281153
Sorbitane Trioleate sc-281154 Mixture of the partial tri-esters of sorbitol and its mono- and di-anhydrides with oleic acid
Sucrose monocaprate sc-281159
Sucrose monolaurate sc-281160 A non-ionic detergent for the solubilization of membrane proteins and growth inhibitor of Listeria monocytogenes.
Taurochenodeoxycholic Acid, Sodium Salt sc-281162 Detergent useful for the solubilization of lipids and membrane-bound proteins. Inhibits Na+-dependent taurocholate transport in the intestine.
Sodium taurocholate sc-281163 Detergent useful for the solubilization of lipids and membrane-bound proteins. Aggregation number 4. CMC 3–11 mM. Micellar weight 2100. pKa 1.9.
Taurodeoxycholic Acid, Sodium Salt sc-281164 Detergent useful for the solubilization of lipids and membrane-bound proteins. Aggregation number: 6. CMC 1 - 4 mM. pKa 1.9.
Tauroursodeoxycholic Acid, Sodium Salt sc-281165 Detergent useful for the solubilization of lipids and membrane-bound proteins.
Tergitol® sc-253623 Polyglycol ether (nonionic) surfactants.
Tergitol® NP-10 sc-281166 A polyglycol ether (nonionic) surfactant.
Tetraethylene glycol monododecyl ether sc-281576 A well-characterised, non-ionic surfactant commonly used in industrial formulations.
Tetraethylene glycol monohexadecyl ether sc-281577 Surfactant used in gel-emulsion preparation.
Tetraethylene glycol monooctyl ether sc-253671 Useful in solubilizing membrane proteins.
Thonzonium bromide sc-281578 Mono-catioinc detergent that has been used in the preparation of pDNA condensed particles.
Triethylene glycol monodecyl ether sc-281176 Non-ionic surfactant. Has been used to study the sodium current of the squid giant axon; Effectively releases histamine from the cell granules of rat peritoneal mast cells
Triethylene glycol monooctyl ether sc-253750 Useful for solubilising membrane proteins.
Tris dodecyl sulfate sc-281179 Buffer. Used in conjunction with 4-picoline laury sulfate in a two-dimensional electrophoresis.
TRITON X-100 Detergent, Hydrogenated sc-281181 Nonionic detergent used for the solubilization of membrane-bound proteins. Lacks the UV absorbance and fluorescence of TRITON X-100 Detergent which causes interference in spectophotometric monitoring and assays. CMC 250.
Triton X-100 sc-29112 Triton X-100 is a non-ionic surfactant and emulsifier widely used for the solubilization of membranes and recovery of membrane components under mild, non-denaturing conditons.
Tween 85 sc-296674
Tyloxapol sc-255711 A nonionic liquid polymer of the alkyl aryl polyether alcohol type. Employed as a surfactant.
ZWITTERGENT 3-08 Detergent sc-281190
ZWITTERGENT 3-10 Detergent sc-281191
ZWITTERGENT 3-12 Detergent sc-281192
ZWITTERGENT 3-16 Detergent sc-281194

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