epitope mapping within an internal region of WIPI-3 of human origin
recommended for detection of WIPI-3 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with other WIPI family members; also reactive with additional species, including equine, canine, bovine, porcine and avian
WIPI-3 Background Information WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WIPI-3 (WD repeat domain phosphoinositide-interacting protein 3), also known as WD repeat-containing protein 45-like or WIPI49-like protein, is a 344 amino acid protein that is ubiquitously expressed with highest levels found in pancreas, heart and skeletal muscle. Upregulated in uterine and ovarian cancer, WIPI-3 contains two WD domains, seven WD40 domains, and is encoded by a gene that maps to human chromosome 17. Chromosome 17 comprises over 2.5% of the human genome, encodes over 1,200 genes and is associated with two key tumor suppressor genes, namely, p53 and BRCA1.
