EBF3 Background Information B lymphocyte maturation is an intricate process that requires a distinct set of transcription factors with respect to the stage of cell differentiation and cell lineage. Among the transcriptional regulators involved in the early stages of B cell development, early B cell factor 3 (EBF3) targets promoter elements for B lymphoid kinase (Blk) and genes encoding portions of the early stage B cell receptors (BCR), which are necessary for initiation of Ig light chain gene recombination and Src kinase (Blk) signaling. EBF3 is a nuclear transcription factor that is highly expressed in brain and exists as either a homodimer or a heterodimer with related family members. Specifically, EBF3 exhibits transcriptional activation activity on target genes by interacting with the core DNA sequence, CCCNNGGG, through a DNA-recognition domain containing a zinc-coordination motif. Two isoforms of EBF3 exist due to alternative splicing events.
EBF3 (N7Q)
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EBF3 (N7Q): sc-81999. Western blot analysis of EBF3 expression in IMR-32 whole cell lysate.
