Rab 43 (QK-07) Antikörper: sc-81923

Rab 43 Background Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies. Increasing data suggests an important role for Rab proteins in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 43, also known as ISY1, Rab 41 or Rab 11B, is a widely expressed member of the Rab family of proteins. Localizing to the Golgi complex, Rab 43 is required for retrograde trafficking to the trans-Golgi and for the biogenesis and maintenance of the Golgi structure. In addition, Rab 43 is a target of the GTPase activating protein (GAP) RN-tre.