epitope mapping near the N-terminus of BAT5 of human origin
recommended for detection of BAT5 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including canine, bovine and porcine
TransCruz reagent for Gel Supershift and ChIP applications, sc-79867 X, 200 µg/0.1 ml
BAT5 Background Information On human chromosome 6, Major histocompatibility complex (MHC) class I and II gene clusters are separated by a 700-kb stretch of sequence known as the MHC class III region. This extremely dense region contains very few genes that have been functionally characterized. MHC class III molecules have very different functions than class I and II molecules. Rather than playing direct roles in the innate and adaptive immune responses, class III molecules encode for products of immunity such as complement components and cytokines. HLA-B-associated transcripts (BATs) map within the MHC class III gene region, which also includes the genes for TNF-å and TNF-∫. BAT5 (HLA-B-associated transcript 5), also known as Protein G5, is a 558 amino acid multi-pass membrane protein that belongs to the BAT family. The gene encoding BAT5 maps within a cluster of BAT genes that is implicated in the development of rheumatoid arthritis and insulin-dependent diabetes mellitus (IDDM).
