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- mouse monoclonal IgG1, 50 µg/1 ml
- raised against full length NALP1 of human origin
- recommended for detection of NALP1 of human origin by WB, IP, IF and IHC(P)
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NALP1 Background Information
NACHT-, LRR- and PYD-containing protein 1 (NALP1), also designated caspase recruitment domain protein 7, is a cytoplasmic protein. NALP1 contains a putative nucleotide binding site, a region of leucine-rich repeats and death domain folds at both termini, providing protein/protein association functions such as caspase recruitment. NALP1 is involved in the innate immune response and is a component of the inflammasome. It forms cytoplasmic structures called death effector filaments and enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. NALP1 is widely expressed in thymus, heart, spleen and peripheral blood leukocytes.
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NALP1 (6D598)
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NALP1 (6D598): sc-71641. Western blot analysis of NALP1 expression in non-transfected: sc-117752 (A) and human NALP1 transfected: sc-116236 (B) 293T whole cell lysates. NALP1 (6D598): sc-71641. Immunofluorescence staining of methanol-fixed NALP1 transfected 293T cells showing cytoplasmic localization.
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