epitope mapping within an internal region of L-xylulose reductase of human origin
recommended for detection of L-xylulose reductase of mouse, rat and human origin by WB, IF and ELISA; also recommended for detection of lung NADPH-dependent carbonyl reductase in mouse; also reactive with additional species, including equine, canine and bovine
L-xylulose reductase Background Information L-xylulose reductase (XR), also called kidney dicarbonyl reductase (kiDCR) or sperm surface protein P34H, is a 244 amino acid member of the short-chain dehydrogenases/reductases family. This peripheral membrane protein catalyzes NADPH-dependent reduction of mulitple sugars, including L-xylulose, to the osmolyte xylitol. Producing xylitol in the renal tubules can prevent osmotic stress. L-xylulose reductase functions as a homotetramer and is expressed highly in kidney, liver and epididymis. Essential pentosuria is the result of a partial deficiency of L-xylulose reductase. Red blood cells of normal individuals contain two L-xylulose reductases: a major and a minor isozyme. Red cells from patients with pentosuria contain only one isozyme. Due to its role in the uronate cycle of glucose metabolism, L-xylulose reductase has been implicated in the management of the long term complications of diabetes.
