NALP11 Background Information The NACHT-, LRR- and PYD-containing protein (NALP) family functions in the regulation of apoptosis and inflammatory signaling pathways. Members of the NALP family (also designated Pyrin-containing APAF1-like proteins) include NALP1 through NALP11. Several family members, such as NALP1, NALP2, NALP3 and NALP6, influence NF˚B and caspase pathways as components of the inflammasome. NALP11 is a 1,033-amino acid member of the NALP family with the the typical PYD-NACHT-LRR domain structure. It is implicated in the activation of proinflammatory caspases via its involvement in multiprotein complexes called inflammasomes.
