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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to amino acids 65-106 mapping near the N-terminus of FBP1 of human origin
- recommended for detection of FBP1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- TransCruz reagent for Gel Supershift and ChIP applications, sc-48821 X, 200 µg/0.1 ml
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| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Human |
FUBP1 |
8880 |
1p31.1 |
NM_003902 |
Q96AE4
|
603444 |
| Maus |
Fubp1 |
51886 |
3 H3 |
|
Q91WJ8
|
n.n. |
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FBP1 Background Information
Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation.
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FBP1 (H-42)
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FBP1 (H-42): sc-48821. Western blot analysis of FBP1 expression in AML-193 whole cell lysate.
FBP1 (H-42): sc-48821. Western blot analysis of FBP1 expression in non-transfected: sc-117752 (A) and mouse FBP1 transfected: sc-120211 (B) 293T whole cell lysates. FBP1 (H-42): sc-48821. Western blot analysis of FBP1 expression in non-transfected: sc-117752 (A) and human FBP1 transfected: sc-171763 (B) 293T whole cell lysates. |
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