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- mouse monoclonal IgG2a, 200 µg/ml
- specific for an epitope mapping between amino acids 160-193 within an internal region of LOX of human origin
- recommended for detection of Lysyl oxidase (LOX) of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and porcine
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LOX Background Information
The lysyl oxidase family of extracellular proteins includes LOX and four LOX-like enzymes, which are responsible for the deamination of peptidyl lysine residues of collagens and elastin. They also catalyze inter- and intra-crosslinking reactions. Overexpression of LOX may cause severe fibrotic degeneration due to its high resistance to degradative enzymes. Procollagen C-proteinase activity processes LOX from a precursor protein to a mature form. Activation of LOX occurs in normal developing and adult skin, and alterations in LOX expression and activity are associated with skin aging and senescence. LOX is crucial for development of the cardiovascular and respiratory systems. In addition, LOX plays a role in cancer, wound healing, as well as cell motility, chemotaxis and differentiation. |
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LOX (F-8)
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LOX (F-8): sc-373995. Western blot analysis of LOX expression in WI 38 whole cell lysate.
LOX (F-8): sc-373995. Immunofluorescence staining of methanol-fixed HeLa cells showing cell surface localization.
LOX (F-8): sc-373995. Immunofluorescence staining of formalin-fixed Hep G2 cells showing cell surface localization.
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