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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to amino acids 21-80 mapping within an N-terminal extracellular domain of ETAR of human origin
- recommended for detection of all ETAR isoforms of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
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| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Human |
EDNRA |
1909 |
4q31.23 |
NM_001957 |
P25101
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157300 |
| Maus |
Ednra |
13617 |
8 C1 |
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Q61614
|
n.n. |
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ETAR Background Information
Endothelin receptor A (ETAR), also known as EDNRA, ET1 Receptor, ETA, EDN1 and ET-AR is a member of the Guanine-binding regulatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodium-potassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. In addition, ETAR induces arachidonic acid accumulation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascular smooth muscle cells (PVSMCs) exclusively express ETAR.
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ETAR (H-60)
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ETAR (H-60): sc-33535. Western blot analysis of ETAR expression in mouse heart (A) and mouse lung (B) tissue extracts.
ETAR (H-60): sc-33535. Western blot analysis of ETAR expression in non-transfected: sc-117752 (A) and human ETAR transfected: sc-170072 (B) 293T whole cell lysates. ETAR (H-60): sc-33535. Western blot analysis of ETAR expression in rat testis tissue extract.
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