epitope mapping within a C-terminal calcium binding domain of S-100A13 of human origin
recommended for detection of S-100A13 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine and canine
S-100A13 Background Information The S-100 protein family consists of a group of calcium-binding proteins, that exhibit cell and tissue-specific expression. The expression levels of its members differ in various pathological conditions. The extracellular functions of the S-100 family may include the ability to enhance neurite outgrowth, involvement in inflammation and motility of tumor cells. S-100A13 is a 98 amino acid protein with two EF-hand calcium-binding domains. High levels of S-100A13 mRNA are present in skeletal muscle, heart, kidney, ovary, small intestine and pancreas. S-100A13 translocates in response to elevated intracellular calcium levels induced by Angiotensin II. S-100A13 co-localizes with S-100A1 on human chromosome 1q21, the site where the majority of S-100 proteins cluster.
