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- goat polyclonal IgG, 200 µg/ml
- epitope mapping near the N-terminus of Drebrin of human origin
- recommended for detection of Drebrin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-30395 P
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Drebrin Background Information
Drebrins (Developmentally regulated brain proteins) are cytoplasmic proteins that bind F-actin in the brain and are involved in cell migration, extension of neuronal processes, and plasticity of dendrites. There are three isoforms: two embryonic types (E1 and E2), and an adult type (A) that are generated by alternative RNA splicing from a single Debrin gene. Drebrins are expressed mainly in brain neurons but are also found in skeletal muscle, heart, placenta, pancreas, and kidney. Drebrin has been designated as a marker of the dendritic spine. Decreases in Drebrin levels in the brain are associated with Alzheimer’s disease and Down syndrome. The gene encoding for the human Drebrin protein is located on chromosome 5. |
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Drebrin (V-20)
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Drebrin (V-20): sc-30395. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.
Drebrin (V-20): sc-30395. Western blot analysis of Drebrin expression in non-transfected 293T: sc-117752 (A), mouse Drebrin transfected 293T: sc-119845 (B) and K-562 (C) whole cell lysates. |
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