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- mouse monoclonal IgG1, 200 µg/ml
- specific for an epitope mapping between amino acids 605-641 near the C-terminus of FBP1 of human origin
- recommended for detection of FBP1 and, to a lesser extent, FBP2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for Gel Supershift and ChIP applications, sc-271241 X, 200 µg/0.1 ml
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FBP1 Background Information
Activation of FUSE, the far upstream element, is required for the proper ex-pression of the mammalian gene c-Myc in undifferentiated cells. The binding of FBP1 (FUSE-binding protein or far upstream element-binding protein) to FUSE is necessary for c-Myc expression, indicating that FBP1 functions as a growth-dependent regulator of c-Myc expression. Isolated from proliferating HL-60 cells, FBP1 (FBP), FBP2 and FBP3 comprise a family of single-stranded DNA-binding proteins that specifically bind to FUSE elements. The FBP transcription factors share a conserved central DNA-binding domain and show significant homology in their carboxyl-terminal activation domains. Expression of FBP1 is detected in undifferentiated cells and is substantially decreased following cellular differentiation. |
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FBP1 (G-8)
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FBP1 (G-8): sc-271241. Western blot analysis of FBP1 expression in HL-60 whole cell lysate.
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