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- Technische Daten
- Im Angebot als 5 mg (sc-253820)
- CAS Nummer: 136647-02-4
- Molekulargewicht: 466.05
- Summenformel: C29H35NO2 ·HCl
- Reinheit: ≥98%
- Physisches Aussehen: white to off-white solid
- Löslichkeit: Soluble in DMSO:10 mg/mL
- SMILES: COC1=CC=C(C=C1)CCCN2CCC(CC2)COC(C3=CC=CC=C3)C4=CC=
CC=C4
- Beschreibung
- UK-78282 blocks Kv1.3 and Kv1.4, which are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. Kv1.3 also maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
- LAGERUNG:
- Sicherheit
- UN Nummer: UN 3077, Class 9, Packing group III
- Wassergefährdungsklasse (WGK): 3
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- Weitere Referenznummern
- Literaturhinweise
- Liang X, et al., Synthesis of UK-78282. Zhongguo Yiyao Gongye Zazhi 4th ed., 36, 193-195, (2005)
Hanson, D.C., et al., UK-78282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br. J. Clin. Pharmacol. 8th ed., 126, 1707-1716, (1999)
Burgess L.E., et al., The SAR of UK-78282: a novel blocker of human T cell Kv1.3 potassium channels. Bioorg. Med. Chem. Lett. 8th ed., 7, 1047-1052, (1997)
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UK-78282 monohydrochloride
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