 |
- Technische Daten
- Im Angebot als 50 mg (sc-253550)
- CAS Nummer: 101526-62-9 (non-salt)
- Molekulargewicht: 367.89
- Summenformel: C14H23N3O3S··HCl•H2O
- Physisches Aussehen: white solid
- Löslichkeit: Soluble in water: ≥16 mg/mL
- SMILES: CCN(CC)CCNC(=O)C1=CC=C(C=C1)N[S+](=O)(C)[O-].O.Cl
- Beschreibung
- A class III antiarrhythmic compound showing selective delayed rectifier K+ current channel blocking. It has been shown to inhibit rapidly activating lk in atrial myocytes in guinea pigs. This results in the prolongation of AP duration and refractor capacity. Has exhibited proarrhythmic effects, potentailly leading to QT interval prolongation.
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- Weitere Referenznummern
- Literaturhinweise
- 1. Yoshida, H., et al, Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model Circ. J. 66, 758-762
2. Ishii, Y., et al., Effects of sematilide, a novel class III antiarrhythmic agent, on delayed rectifier K+ current in guinea pig atrial myocytes Jpn. J. Pharmacol. 71, 361-365, (1996)
|
Lieferzeit: 3-5 Werktage
|
| |
|
|
|
Sematilide monohydrochloride monohydrate
Klicken Sie auf das Bild um es zu vergrößern.
|
|
|
Download
|
|
