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- Technische Daten
- Im Angebot als 10 mg (sc-252383)
- CAS Nummer: 33237-74-0
- Molekulargewicht: 358.95
- Summenformel: C22H30N2•HCl
- Reinheit: ≥98%
- Produktform: Solid
- Physisches Aussehen: solid
- Löslichkeit: Soluble in water: >10 mg/mL
- SMILES: CCN(CC)CCCN(C1CC2=CC=CC=C2C1)C3=CC=CC=C3.Cl
- Beschreibung
- Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3':5'-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
- LAGERUNG:
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- Weitere Referenznummern
- PubChem Compound ID: 71413
- Literaturhinweise
- De Bruin, M.L., et al., Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death. Eur. Heart J. 26, 590-597, (2005)
Levine, S.N., and Hollier, B., Aprindine inhibits calmodulin-stimulated phosphodiesterase and Ca-ATPase activities. J. Cardiovasc. Pharmacol. 5, 151-156, (1983)
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Aprindine hydrochloride
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