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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of Pdcd-2 of human origin
- recommended for detection of Pdcd-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- blocking peptide, sc-22975 P
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Pdcd-2 Background Information
Pdcd-1 (Programmed Cell Death-1 protein) is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. Pdcd-1 contains an immunoreceptor tyrosine based inhibitory motif (ITIM) within the cytoplasmic domain, which is conserved between the mouse and human homologs. Expression of Pdcd-1 is detected in mouse thymus, and it is induced in stimulated B and T cell lines, where it may play a role in thenegative regulation of various immune responses. Receptors such as Pdcd-1 function by recruiting tyrosine phosphatases, including SHP-1 and SHIP, which are responsible for altering various B cell responses. Additionally, in activated lymphocytes, Pdcd-1 mediates the activation of the classical type of programmed cell death. A related protein, Pdcd-2 (also known as PD-2, PDL2, or B7DC), is highly expressed in placenta, heart, pancreas, lung, and liver, and lowly expressed in spleen, lymph nodes, and thymus. |
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Pdcd-2 (C-20)
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Pdcd-2 (C-20): sc-22975. Western blot analysis of Pdcd-2 expression in non-transfected: sc-117752 (A) and human Pdcd-2 transfected: sc-176420 (B) 293T whole cell lysates. |
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