p53AIP1 (H-91) Antikörper: sc-22761

p53AIP1 Background Information
p53 is a tumor suppressor gene or anti-oncogene that has been shown to induce apoptosis by means of a direct signaling pathway (1). For example, when severe DNA damage or a mutation occurs, ser-46 on p53 is phophorylated, p53AIP1 (p53-regulated Apoptosis-Inducing Protein 1) is expressed and apoptosis is induced (2,3). However, when ser-46 is substituted, the expression of p53AIP1 is blocked, and apoptosis is inhibited (2). Expression of p53AIP1 is strictly controlled by p53 under specific conditions and is inducible by p53 (2). The expression of p53AIP1 causes apoptosis in some, but not all p53-mutated cancer cells (4). p53AIP1 is ectopically expressed within the mitochondria in a wide variety of tissue types, excluding the thymus (2,5). Overexpression of the p53AIP1 gene causes dissipation of mitochondrial membrane potential which further suggests a key role for p53AIP1 in the regulation of apoptosis (5).