Prodrug of the KATP channel opener Y-26763. Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Orally active in vivo, produces long-lasting antihypertensive effects with minimal tachycardia following oral administration in hypertensive animals.
LAGERUNG:
Store at room temperature
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197.
