hERG K+ channel activator. Displays different molecular mechanisms of action at hERG1 and hERG2 channels. Exhibits antiarrhythmic activity in vitro.
LAGERUNG:
SOLIDS: Provided storage is as stated on the product label
and the vial is kept tightly sealed, the product can be stored
for up to 6 months from date of receipt.
SOLUTIONS: We recommend that stock solutions, once
prepared, are stored aliquoted in tightly sealed vials at -20°
C or below and used within 1 month. Wherever possible
solutions should be made up and used on the same day.
Sicherheit
UN Nummer: UN 2811
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
Hansen et al (2006) Activation of human ether-a-go-go related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643). Mol.Pharmacol. 69 266. Casis et al (2006) Mechanism of action of a novel human ether-a-go-ao related gene channel activator. Mol.Pharmacol. 69 658. Elmedyb et al (2007) Activation of ERG2 potassium channel by the diphenylurea NS1643. Neuropharmacology 53 283.
