Blocker of KCNQ voltage-gated potassium channels; blocks KCNQ2+3/M-currents (IC50 = 4-7 μM) and KCNQ1 homomeric channels (IC50 = 8.9 μM). Increases hippocampal ACh release and is a cognitive enhancer following oral administration in vivo.
LAGERUNG:
Desiccate at room temperature
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
Literaturhinweise
Schnee and Brown (1998) Selectivity of linopirdine (DuP 966), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J.Pharmacol.Exp.Ther. 286 709. Wang et al (1998) KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science 282 1890. Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724.
