Activator of KCNQ1 (KVLQT1) channels; activates the cardiac IKs current that decreases action potential duration (APD) in cardiac myocytes.
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
Literaturhinweise
Salata et al (1998) A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Am.Soc.Pharmacol.Exp.Ther. 53 220. Seebohm et al (2003) Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels. Circ.Res. 93 941. Jow et al (2006) Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). Assay Drug Dev.Technol. 4 443.
