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Harmine (CAS 442-51-3)

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AnwendungenAn alkaloid of the β-carboline family that regulates PPARγ expression.
CAS Nummer442-51-3
Reinheit≥97%
Molekulargewicht212.3
MolekülformelC13H12N2O
Refer to Certificate of Analysis for lot specific data (including water content).
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 Produkte und Bestellinformationen
ProduktKatalog #MengePreis AnzahlKaufFavoriten
Harmine sc-202644 250 mg $30
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Beschreibung
Harmine is an alkaloid of the β-carboline family that regulates PPARγ expression. Harmine inhibits the Wnt signaling pathway in a cell-specific manner. Down-regulates inflammatory gene expression (TNF-α, IL-1β, iNOS). Reversibly inhibits MAO-A (monoamine oxidase A) but has no effect on MAO-B. Harmine is an inhibitor of Dyrk1A, Dyrk2 and Dyrk3.
Hintergrundinformationen
ErscheinungsbildSolid
LöslichkeitSoluble in DMSO (100 mM), DMF (~1.5 mg/ml), ethanol (~1.5 mg/ml), and PBS (pH 7.2, ~0.25 mg/ml). Insoluble in water.
LagerungStore at -20° C
Schmelzpunkt262-264 °C (lit.)
Siedepunkt421.37 °C at 760 mmHg (Predicted)
Dichte1.25 g/cm3 (Predicted)
Brechungsindexn20D 1.71 (Predicted)
IC50:Plasmodium falciparum: IC50 = 28 nM; Dyrk1A: IC50 = 30 nM (human); DYRK1A: IC50 = 0.08 µM; Haspin: IC50 = 0.59 µM (human); Dyrk2: IC50 = 0.69 µM (human)
Ki DatenMAO-A: Ki= 5 nM (human); Nischarin: Ki= 22 nM (human); α2C-AR: Ki= 0.81 µM (human); α2B-AR: Ki= 1.13 µM (human); SR-6: Ki= 1.48 µM (human)
pK Werte:pKa: 13.54 (Predicted), pKb: 8.71 (Predicted)
Hintergrundinformationen
Transport:UN 3077, Class 9, Packing group III
Wassergefährdungsklasse (WGK)3
RTECSUV0175000
PubChem Substanz ID5280953
Merck Index14: 4616
MDL NummerMFCD00004958
EC Nummer207-131-4
Beilstein Registrierung178813
SMILES:CC1=NC=CC2=C1NC3=C2C=CC(=C3)OC
Ausschließlich für Forschungszwecke. Nicht Geeignet für Verwendung in Diagnostik oder Therapie.
Literaturhinweise
1. Coulthard, C.E., et al. 1933. Biochem. J. 27: 727-739. PMID: 16745151
2. Coulthard, C.E., et al. 1934. Biochem. J. 28: 264-267. PMID: 16745362
3. Schmitt, H., et al. 1964. Nature. 203: 877-878. PMID: 14204082
4. Gerardy, J., et al. 1994. Prog. Neuropsychopharmacol. Biol. Psychiatry. 18: 793-802. PMID: 7938567
5. Abdel-Fattah, A.F., et al. 1995. Pharmacol. Biochem. Behav. 52: 421-426. PMID: 8577810
6. Hauner, H., et al. 2002. Diabetes Metab. Res. Rev. 18: S10-S15. PMID: 11921433
7. Chen, Q., et al. 2005. Int. J. Cancer. 114: 675-682. PMID: 15609303
8. Waki, H., et al. 2007. Cell Metab. 5: 357-370. PMID: 17488638
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