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Adenosine 5'-O-(3-thiotriphosphate), tetralithium salt: sc-202039 |
| Datenblatt | MSDS |
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- Technische Daten
- Im Angebot als 1 mg (sc-202039) und 5 mg (sc-202039A) sizes
- CAS Nummer: 93839-89-5
- Molekulargewicht: 547
- Summenformel: C10H12N5O12P3S ·4Li
- Reinheit: 90%
- Physisches Aussehen: White to off-white solid
- Löslichkeit: Soluble in water
- SMILES: [Li+].[Li+].[Li+].[Li+].C1=NC2=C(C(=N1)N)N=CN2C3C(
C(C(O3)COP(=O)([O-])OP
(=O)([O-])OP(=S)([O-])[O-])
O)O
- Beschreibung
- Adenosine 5'-O-(3-thiotriphosphate), tetralithium an unhydrolyzable analogue of ATP which acts as an agonist for P2X2-R, activating calcium channels causing an influx of Ca2+ inside the cell. Studies suggest that keratinocytes stimulated with Adenosine 5'-O-(3-thiotriphosphate), tetralithium salt induce HB-EGF expression and activate EGFR and ERK1/2. In addition, the ATP analogue stimulates the release of IL-8 from the human uroepithelial cell line UROtsa and the human kidney epithelial cell line A498 via purinoceptor agonists that activate P2Y receptors. Neuronal studies suggest that the ATP analogue increases the excitability of lamina IX neurons by membrane depolarization generating an inward current at a holding potential of -70 mV through non-selective cation-channel activation and spontaneous excitatory transmission enhancement.
- LAGERUNG:
- Stock solutions may be stored at -80°C for up to 1 month. Product is not sterile.
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- Weitere Referenznummern
- Literaturhinweise
- 1. Gomes, D.A., et al. 2009. Am. J. Physiol. Regul. Integr. Comp. Physiol. 297: R940-R949. PMID: 19625689
2. Aoyama, T., et al. 2010. Brain Res. 1340: 10-17. PMID: 20423703
3. Säve, S. and Persson, K. 2010. Infect. Immun. 78: 3609-3615. PMID: 20515921
4. Giltaire, S., et al. 2010. J. Cell. Physiol. [Epub ahead of print]. PMID: 21069726
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Adenosine 5'-O-(3-thiotriphosphate), tetralithium salt
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