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- Technische Daten
- Im Angebot als 50 mg (sc-201003) und 250 mg (sc-201003A) sizes
- Synonym: β, β-pentamethylen-gamma-butyrolactam
- CAS Nummer: 64744-50-9
- Molekulargewicht: 153.2
- Summenformel: C9H15NO
- Reinheit: 99%
- Produktform: Solid
- Physisches Aussehen: White solid
- Löslichkeit: Soluble in DMSO (>40 mg/mL) and ethanol (>40 mg/mL)
- SMILES: O=C1CC2(CN1)CCCCC2
- Beschreibung
- Gabapentin-lactam, a cell permeable compound, has been reported to reduce oxygen glucose deprivation-induced [3H]glutamate release in rat ischemia hippocampal slices. Glutamate has been an excitotoxin and its inhibition can decrease the number of surviving ganglion cells in vitro. In mechanistic studies it has been demonstrated that the neuroprotective characteristics of Gabapentin-lactam take effect via opening of ATP-sensitive potassium channels.
- LAGERUNG:
- Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Weitere Referenznummern
- PubChem Compound ID: 47457
- MDL Nummer: MFCD00177938
- Literaturhinweise
- 1. Jehle, T., et al. 2000. Naunyn Schmiedebergs Arch. Pharmacol. 362: 74-81. PMID: 10935536
2. Lagrèze, W.A., et al. 2001. Graefes Arch. Clin. Exp. Ophthalmol. 239: 845-849. PMID: 11789865
3. Pielen, A., et al. 2004. Graefes Arch. Clin. Exp. Ophthalmol. 242: 240-244. PMID: 14770318
4. Zucker, B., et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol. 370: 131-139. PMID: 15322735
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Gabapentin-lactam
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