U-37883A is a potent inhibitor of vascular smooth muscle K-ATP channels. Useful biological tool in distinguishing between Kir6.1 and Kir6.2 chimeric protein functions as well as the different sulfonylurea-sensitive K+ channel subtypes. This product shows significant selectivity for K-ATP channels over KV and KIR channels in smooth muscle cells. K-ATP channel block induced relaxation of rat middle meningeal arteries in vivo and in vitro. U-37883A has potential diuretic properties.
LAGERUNG:
Store as supplied at room temperature for up to 1 year. Store solutions at -
20° C for up to 1 month.
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
