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- Technische Daten
- Im Angebot als 1 mg (sc-200997) und 5 mg (sc-200997A) sizes
- CAS Nummer: 12627-35-9
- Molekulargewicht: 634.2
- Summenformel: C37H44ClNO6
- Reinheit: ≥96%
- Gewonnen aus: Penicillium palitans
- Physisches Aussehen: White to off white solid
- Löslichkeit: Methanol (10 mg/ml), acetone or DMSO
- SMILES: CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8
CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
- Beschreibung
- Penitrem A, a potent neurotoxin produced by several species in the genus Penicillium, displays a capacity to have numerous effects on ion channels and neurotransmitter release. This compound has also been reported to inhibit binding of [125I]charybdotoxin (ChTX) to maxi-K channels in bovine aortic smooth muscle sarcolemmal membranes. Additionally, Penitrem A shows the ability to induce an increase in the voltage and frequency of electrical activity recorded from the cerebral cortex.
- LAGERUNG:
- Store as supplied at -20° C for up to 1 year. Store solutions at -20° C for up to 3
months.
- Sicherheit
- UN Nummer: UN 3462, Class 6.1, Packing group II
- Risiko-Sätze: R26,R27,R28
- Sicherheits-Sätze: S36,S37,S39,S45
- Wassergefährdungsklasse (WGK): 3
- RTECS: RY7535000
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Weitere Referenznummern
- PubChem Compound ID: 4732
- MDL Nummer: MFCD00083465
- Literaturhinweise
- 1. Knaus, H.G., et al. 1994. Biochemistry. 33: 5819-5828. PMID: 7514038
2. Breton, P., et al. 1998. Toxicon. 36: 645-655. PMID: 9643478
3. Moldes-Anaya, A., et al. 2009. Drug Chem Toxicol. 32: 26-37. PMID: 19514936
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Penitrem A
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