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- Technische Daten
- Im Angebot als 1 g (sc-200980)
- CAS Nummer: 364-98-7
- Molekulargewicht: 230.7
- Summenformel: C8H7ClN2O2S
- Reinheit: ≥98%
- Physisches Aussehen: White solid
- Löslichkeit: Soluble in DMSO (25 mg/ml), NaOH (0.1 M) and methanol. Insoluble in water.
- SMILES: CC1=NS(=O)(=O)C2=C(N1)C=CC(=C2)Cl
- Beschreibung
- Diazoxide is a benzothiadiazine derivative which functions as a selective ATP-dependent K+ channel activator and calcium channel blocker. As a result membrane permeability increases the flow of K+ across the membrane, which turns off voltage gated calcium channels. This inhibition in action potential causes a relaxation in smooth muscle. Studies suggest that Diazoxide acts as a peripheral vasodilator. In addition, Diazoxide is used in diabetic studies to increase glucose concentrations in plasma, inhibit the secretion of insulin by β cells of the pancreas, increase the release of catecholamines, and hepatic output of glucose.
- LAGERUNG:
- Store at room temperature
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- Weitere Referenznummern
- PubChem Compound ID: 3019
- Literaturhinweise
- 1. Trube, G., et al. 1986. Pflugers Arch. 407: 493-499. PMID: 2431383
2. Quast, U., et al. 1989. J. Pharmacol. Exp. Ther. 250: 261-271. PMID: 2501478
3. Dunne, M.J., et al. 1990. J. Membrane Biol. 114: 53-60. PMID: 2181144
4. Newgreen, D.T., et al. 1990. Br. J. Pharmacol. 100: 605-613. PMID: 2167738
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Diazoxide
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