 |
- Technische Daten
- Im Angebot als 100 µg (sc-200979)
- CAS Nummer: 95751-30-7
- Molekulargewicht: 4323.98
- Summenformel: C176H289N57O56S7
- Reinheit: >91%
- Physisches Aussehen: Lyophilized solid.
- Löslichkeit: Soluble in water (1 mg/ml)
- SMILES: CC(C)CC(C(=O)NC(CC1CNCN1)C(=O)NC(CC(=O)N)C(=O)NC(C
(C)O)C(=O)NC(CO)C(=O)
NC(CCCNC(=N)N)C(=O)NCC(=O)NC
(CCCCN)C(=O)NC(CS)C(=O)NC(CCSC)C(=O)NC(CC(=
O)N)C(
=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CS)C(=O)NC(CCCNC
(=N)N)C(=O)NC
(CS)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(
CO)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C
(CCC(=O)N)NC(
=O)C(CS)NC(=O)C(C(C)C)NC(=O)C(CO)NC(=O)C(CC3=CNC4=
CC=CC=
C43)NC(=O)C(CS)NC(=O)C(CCC(=O)O)NC(=O)C(CCC
CN)NC(=O)C(CO)NC(=O)C(C(C)O)
NC(=O)C(C(C)O)NC(=O)C
(CS)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)N)NC(=O
)
C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)N
- Beschreibung
- Peptide found in the venom of the scorpion Leiurus quinquestriatus. High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel inhibitor. A potent and selective blocker of the large conductance Ca2+-activated K+, Slo channels in nanomolar concentrations as well as Kv1.2 (Kd = 14 nM) and Kv1.3 (Kd = 2.6 nM) channels. Present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
- LAGERUNG:
- Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
- The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
- Weitere Referenznummern
- Literaturhinweise
- 1. Miller, C., et al. 1985. Nature. 313: 316-318. PMID: 2578618
2. Price, M., et al. 1989. Proc. Natl. Acad. Sci. U.S.A. 86: 10171-10175. PMID: 2481312
3. MacKinnon, R., et al. 1989. Science. 245: 1382-1385. PMID: 2476850
4. Deutsch, C., et al. 1991. J. Biol. Chem. 266: 3668-3674. PMID: 1704892
5. Grissmer, S., et al. 1994. Mol. Pharmacol. 45: 1227-1234. PMID: 7517498
6. Giménez, J., et al. 1994. Toxicon. 32: 1137-1146. PMID: 7801349
|
|
| |
|
|
|
Charybdotoxin
Klicken Sie auf das Bild um es zu vergrößern.
|
|
|
Download
|
|
