Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2 but not PLC or PLD. It has been suggested that isotetrandrine suppresses the receptor-mediated phospholipase A2 activation by uncoupling a GTP-binding protein from the enzyme. It has been reported to inhibit collagen, thrombin, and arachidonic acid-induced platelet aggregation. It has been found to inhibit arachidonic acid liberation of platelets induced by compound 48/80, antigen, GTP gamma S and Ca2+.
LAGERUNG:
Store as supplied at -20° C for up to 1 year. Store solutions at -20° C for up to 3
months.
Sicherheit
RTECS: NX7285000
Ausschließlich für Forschungszwecke (in-vitro, laboratory research use only)
The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
