NADSYN1 (S-15) Antikörper: sc-168703

NADSYN1 Background Information
NAD (nicotinamide adenine dinucleotide) is a cofactor that participates in a wide variety of functions, including metabolic redox reactions, cell signaling events and post-translational protein modifications. The synthesis of NAD within the cell is dependent upon a number of enzymes, called NAD synthetases, that work in concert to catalyze the reactions that form NAD. NADSYN1 (NAD synthetase 1) is a 706 amino acid protein that contains one CN (carbon-nitrogen) hydrolase domain and is a member of the NAD synthetase family. Expressed at high levels in testis, kidney, liver and small intestine, NADSYN1 catalyzes the ATP-dependent conversion of deamido-NAD+ to free NAD+. NADSYN1 exists as a homohexamer that uses both ammonia and glutamate as amide donors. NADSYN1 is present in human promyelocytic leukemia and glioma cell lines, suggesting a possible role in tumor formation.