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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of KCNE1 of human origin
- recommended for detection of KCNE1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, porcine and feline
- blocking peptide, sc-16796 P
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| Spezies |
Gen |
Gen ID |
Chromosomaler Locus |
mRNA (Isoform) Accession # |
Protein Accession # |
OMIM™ Nummer |
| Human |
KCNE1 |
3753 |
21q22.12 |
NM_000219 |
P15382
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220400 |
| Maus |
Kcne1 |
16509 |
16 C4 |
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P23299
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n.n. |
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KCNE1 Background Information
Voltage-gated K+ channels in the plasma membrane control the repolarization and the frequency of action potentials in neurons, muscles, and other excitable cells. KCNE1 and KCNE2 are two single transmembrane domain b subunits of the delayed rectifier potassium channel IKr. In cardiac tissue, KCNE2 (also known as MiRP1) assembles with HERG, the pore-forming a subunit of IKr. In the brain, KCNE2 associates with KCNQ2 and accelerates the dissociation of KCNQ2 from the KCNQ2-KCNQ3 complex. KCNE2 also regulates the current amplitude and gating properties of the KCNQ1 K+ channel, and may assemble with KCNQ1 in the stomach to aid in K+ recycling, which is necessary for gastric acid secretion. The gene encoding human KCNE2 maps to chromosome 21q22.12. Missense mutations in the gene for KCNE2 result in congenital long QT syndrome and drug-induced cardiac arrhythmia.
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KCNE1 (N-16)
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KCNE1 (N-16): sc-16796. Western blot analysis of KCNE1 expression in rat heart tissue extract.
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